Resumen Se describe la experiencia de un proyecto de huerta terapéutica ubicada en las inmediaciones del Servicio de psiquiatría del Hospital Guillermo Grant Benavente (HGGB) de Concepción, Chile, liderada por la Organización No Gubernamental Rebrota (ONG Rebrota) en base a la perspectiva eco-social aplicada en personas con necesidades de salud mental. Se objetiva analizar la experiencia de Terapia Ocupacional Ecosocial como herramienta práctica para la transformación de los territorios, permitiendo a los terapeutas ocupacionales comprender la interacción entre la sociedad y la naturaleza como un proceso socioecológico que impacta en diferentes esferas de los seres humanos, especialmente en la participación social y la salud mental. Utilizando la metodología descriptiva del Modelo Procesal de Emprendimiento Eco-social realizamos una orientación práctica de acciones para que las comunidades, insertas en sus entornos naturales y culturales, logren descubrirse reflexivamente generando procesos de salud colectiva. La Terapia Ocupacional Ecosocial desarrolla praxis que mejoran la salud y promueven el bienestar de las personas, grupos y/o comunidades, generando un impacto positivo en los socio-ecosistemas y construyen comunidades más saludables, inclusivas, sostenibles. La Terapia Ocupacional Ecosocial es una invitación a generar proyectos de investigación-acción para mitigar el impacto social sobre la naturaleza en un contexto de crisis climática, donde encontramos comunidades en la génesis de saberes transculturales que nos permitan desarrollar una praxis transformadora para el buen vivir en sintonía con nuestro entorno; mientras mejoran su bienestar y participación, desde una perspectiva de derechos humanos y justicia ocupacional. HGGB (HGGB Concepción Chile ONG ecosocial eco mental territorios Eco culturales colectiva yo o socioecosistemas socio ecosistemas saludables inclusivas sostenibles investigaciónacción investigación acción climática entorno ocupacional

Abstract It is described the experience of a therapeutic garden project located in the vicinity of the Psychiatry Service of the Guillermo Grant Benavente Hospital (HGGB) in Concepción, Chile, led by the Non-Governmental Organization Rebrota (ONG Rebrota) based on the ecosocial perspective applied in people with mental health needs. It aims to analyze this Eco-social Occupational Therapy experience as a practical tool for the transformation of territories, allowing occupational therapists to understand the interaction between society and nature as a socio-ecological process that impacts different spheres of human beings, especially in social participation and mental health. Using the descriptive methodology of the Eco-social Entrepreneurship Process Model, we carry out a practical orientation of actions so that communities, inserted in their natural and cultural environments, can discover themselves reflexively, generating collective health processes. Eco-social Occupational Therapy develops practices that improve health and promotes the well-being of individuals, groups and/or communities, generating a positive impact on socio-ecosystems and building healthier, more inclusive, and sustainable communities. Eco-social Occupational Therapy is an invitation to generate research-action projects to mitigate the social impact on nature in a context of the climate crisis, where we find communities in the genesis of transcultural knowledge that allows us to develop a transformative praxis for good living in tune with our environment; while improving their well-being and participation, from a human rights and occupational justice perspectives. HGGB (HGGB Concepción Chile NonGovernmental Non Governmental ONG needs Ecosocial Eco territories socioecological socio ecological beings Model environments reflexively processes wellbeing well being individuals andor or socioecosystems ecosystems healthier inclusive researchaction research action crisis environment perspectives

Background: IgG4-related disease (IgG4 RD) is an immune-mediated fibro-inflammatory disorder, with tissue infiltration of IgG4+ plasma cells. It causes pseudotumors, tumors, and a wide spectrum of clinical manifestations. Aim: To report the clinical, laboratory, histopathological and treatment characteristics of a group of Chilean patients with IgG4 RD. Material and Methods: Review of medical records of 52 patients aged 18 to 76 years with IgG4 RD seen at six medical centers. Results: Elevated IgG4 serum levels (> 135 mg/dl) were found in 18 of 44 (41%) patients. There was histological confirmation of the disease in 46 patients. The most common sites of involvement were lungs, eyes and kidneys. Eighteen (35%) patients had only one organ involved, 34 (65%) patients had two organs and 13 (25%) patients had three or more organs. The involvement of two organs was significantly more common in men (p < 0.05). In patients with only one organ involvement, the most frequent location was orbital and meningeal. All patients with kidney or lung disease had multiorgan involvement. All patients received corticosteroid therapy, 67% synthetic immunosuppressants, and 16% rituximab. Conclusions: ER-IgG4 can affect any tissue. Multiorgan involvement was more common in this series, with preference for lungs, eyes and kidneys. An excellent response to steroids is characteristic of the disease, but with a high relapse rate that requires additional immunosuppression.

Abstract: The Diego Ramírez archipelago is the last point of the South-America continent, located in the Drake Passage 112 km SW of Cape Horn. Due to its difficult access, information on the marine biodiversity that inhabits its coasts is still limited. This study presents the first report of the assemblage of coastal marine mollusks in this archipelago. Samples were collected during an expedition to Gonzalo Island during the spring of 2016. During the low tide an exhaustive inspection and collection of mollusks was carried out from the upper intertidal zone to 1 m depth. Records of these collections were complemented with reports from previous expeditions. A total 51 mollusk taxa were identified. Among the identified taxa, 42 mollusk species were new to Diego Ramirez Islands. This work is an updated list record of mollusks of the Diego Ramírez archipelago. It is important to continue investigating and monitoring this archipelago which corresponds to the southern limit of the Magellanic Province and the last South American rocky remnants that face the Drake passage.

Resumen: El archipiélago Diego Ramírez es el último confín del continente Sudamericano y se encuentra ubicado en el Paso Drake, a 112 km al SO del Cabo de Hornos aproximadamente. Debido a su difícil acceso, la información sobre la biodiversidad marina que habita sus costas es todavía limitada. En este estudio se presenta el primer catastro del ensamble de moluscos costero-marinos en este archipiélago, basado en la expedición a isla Gonzalo y en las colectas realizadas en esta isla en la primavera del año 2016. Durante marea baja se efectuó una exhaustiva inspección y colecta de moluscos desde la zona del intermareal superior hasta 1 m de profundidad. Para los análisis, los registros de estas colectas se complementaron con reportes de expediciones anteriores. De esta manera se determinaron 51 taxa de moluscos. Del total de taxa identificados se informan 42 nuevos registros de 42 especies de moluscos para las islas Diego Ramírez. Este estudio corresponde a un catastro actualizado de moluscos del archipiélago Diego Ramírez. Es importante seguir investigando y monitoreando este archipiélago, que corresponde al límite sur de la Provincia Magallánica y a los últimos vestigios rocosos sudamericanos que enfrentan el Paso Drake.

The external morphometrics of shell and radula morphology were performed in two species of micromollusks of the genus Eatoniella in Navarino Island, Chile. A total of 50 specimens of E. picea and 72 of E. nigra were analyzed. These species have similar morphology, but E. picea has a smaller diameter/length ratio (0.53 ± 0.02) than E. nigra (0.61 ± 0.04). In relation to the radula morphology, E. picea has wider middle cuspid teeth and small denticles in its border, meanwhile E. nigra has pointed central cuspid teeth.

RESUMO O sobrepeso e a obesidade constituem uma epidemia global atingindo níveis alarmantes nos países desenvolvidos e em desenvolvimento. O Chile não é exceção: o país tem registrado uma elevação acentuada da prevalência de obesidade, sobretudo em crianças em idade escolar. Este artigo descreve as medidas envolvendo políticas e estratégias implantadas no Chile na última década para combater este importante problema de saúde pública e destaca os principais desafios e as particularidades do processo. O país adotou políticas para rotulagem nutricional na parte da frente da embalagem dos produtos alimentícios, regulamentação da publicidade e restrições aos alimentos servidos em escolas. As novas políticas são direcionadas aos determinantes sociais da saúde por estarem associados aos ambientes e aos comportamentos alimentares da população. Além de serem adaptadas ao contexto atual do Chile, estas medidas se embasam nas melhores evidências científicas. A execução destas políticas deu início a um amplo debate entre as instituições públicas e a indústria de produtos alimentícios envolvendo de questões sobre direitos de propriedade às barreiras comerciais. Apesar das suas posições divergentes sobre alguns aspectos, os interessados diretos chegaram a um consenso político importante. As organizações internacionais esperam agora conhecer o resultado da avaliação do impacto dessas iniciativas pioneiras na América Latina.

ABSTRACT Overweight and obesity are a global epidemic with rates having risen to alarming levels in both developed and developing countries. Chile has been no exemption, with sharp increases in obesity prevalence, especially among school-age children. This paper describes the policy actions and strategies implemented to tackle this major public health concern in Chile over the last 10 years, and highlights the main challenges and nuances of the process. Chile has taken policy action that includes front-of-package labelling, advertising regulations, and school-food restrictions. New policies focus on the social determinants of health as they relate to food environments and people's behavior. These actions are not only suitable to the current context in Chile, but are also supported by the best available scientific evidence. Moreover, the implementation of these policies has produced a broad debate involving public institutions and the food industry, with discussions issues ranging from property rights to trade barriers. Despite some differences among stakeholders, a valuable political consensus has been achieved, and several international organizations are eager to evaluate the impact of these pioneer initiatives in Latin America.

RESUMEN El sobrepeso y la obesidad son una epidemia mundial, en la que se registran tasas que han aumentado hasta niveles alarmantes tanto en los países desarrollados como en los países en desarrollo. Chile no ha sido una excepción, con aumentos pronunciados de la prevalencia de la obesidad, especialmente en los niños en edad escolar. En este documento se describen las políticas y estrategias aplicadas para luchar contra este grave problema de salud pública en Chile durante los 10 últimos años, y se resaltan los principales retos y matices del proceso. Chile ha tomado medidas de política que incluyen el etiquetado frontal de los envases, la reglamentación de la publicidad y restricciones en cuanto a la alimentación en las escuelas. Las nuevas políticas se centran en los determinantes sociales de la salud pues guardan relación con el entorno en cuanto a la alimentación y el comportamiento de las personas. Estas medidas no solo son apropiadas para el contexto actual de Chile, sino que también se basan en las mejores pruebas científicas de que se dispone. Por otro lado, la aplicación de estas políticas ha generado un amplio debate con las instituciones públicas y la industria alimentaria, cuyos temas de discusión abarcan desde derechos de propiedad hasta barreras comerciales. A pesar de algunas diferencias entre los interesados directos, se ha logrado un valioso consenso político y varias organizaciones internacionales están dispuestas a evaluar la repercusión de estas iniciativas pioneras en América Latina.

RESUMO Fundamentar o processo de formulação de políticas de saúde com as melhores evidências científicas disponíveis tornou-se indispensável nos sistemas de saúde em todo o mundo. As plataformas de tradução de conhecimento, como as Redes de Políticas Informadas por Evidências (EVIPNet) da Organização Mundial da Saúde (OMS), são parte de uma estratégia comprovada para vincular a pesquisa à ação. Este informe descreve a experiência de implantação da EVIPNet no Chile: dos objetivos, estrutura organizacional, estratégia, atividades e principais resultados à evolução ao longo do primeiro ano de atividade. As lições aprendidas são também apresentadas. Das atividades iniciadas pela EVIPNet-Chile, o Serviço de Resposta Rápida mostrou ser um bom ponto de partida para atrair a participação dos formuladores de políticas. Os seminários de capacitação e os colóquios sobre políticas com os interessados relevantes renderam bons resultados. Além disso, a EVIPNet-Chile elaborou um modelo para atrair a participação das instituições acadêmicas na formulação de políticas com uma rede dedicada ao preparo de resumos de evidências. Um dos muitos desafios identificados é modificar os métodos para produzir sínteses rápidas de evidências. Este modelo de implantação da plataforma de tradução de conhecimento sediado em um ministério da saúde poderia contribuir para a elaboração de iniciativas semelhantes em outros sistemas de saúde.

ABSTRACT Informing the health policymaking process with the best available scientific evidence has become relevant to health systems globally. Knowledge Translation Platforms (KTP), such as the World Health Organization's Evidence Informed Policy Networks (EVIPNet), are a recognized strategy for linking research to action. This report describes the experience of implementing EVIPNet in Chile, from its objectives, organizational structure, strategy, activities, and main outputs, to its evolution over the course of its first year. Lessons learned are also covered. Of the activities initiated by EVIPNet-Chile, the Rapid Response Service proved to be a good starting point for engaging policymakers. Capacity building workshops and policy dialogues with relevant stakeholders were also successful. Additionally, EVIPNet-Chile developed a model for engaging academic institutions in policymaking through a network focused on preparing evidence briefs. A number of challenges, such as changing methods for producing rapid evidence syntheses, were also identified. This KTP implementation model located in a Ministry of Health could contribute to the development of similar initiatives in other health systems.

RESUMEN Para los sistemas de salud a nivel mundial se ha vuelto cada vez más importante contar con la mejor evidencia disponible como información para el proceso de formulación de políticas de salud. Las plataformas de traducción del conocimiento, como la Red de Políticas Informadas por la Evidencia (EVIPNet, por su sigla en inglés) de la Organización Mundial de la Salud, son estrategias reconocidas para vincular la investigación a la acción. En este informe se describe la experiencia de la utilización de EVIPNet en Chile, sus objetivos, estructura orgánica, estrategia, actividades y resultados principales de su evolución en el curso de su primer año. Se incluyen asimismo las enseñanzas extraídas. De las actividades iniciadas por EVIPNet en Chile, el servicio de respuesta rápida resultó ser un buen punto de partida para interesar a los responsables de las políticas. También fueron exitosos los talleres que se llevaron a cabo sobre creación de capacidades y los diálogos de política con los interesados directos pertinentes. Además, EVIPNet en Chile elaboró un modelo para invitar a instituciones académicas a participar en el proceso de formulación de políticas por medio de una red centrada en la preparación de resúmenes de datos científicos. Se encontraron también varios retos, como el cambio de métodos para producir síntesis rápidas de datos científicos. Este modelo de aplicación de plataformas de traducción del conocimiento, ubicado en un Ministerio de Salud, podría contribuir al desarrollo de iniciativas similares en otros sistemas de salud.

Background: It is of utmost importance to identify hypertensive subjects in a country, in order to use efficiently public resources. The National Health Survey 2009-10 in Chile incorporated a third measurement of blood pressure (BP) during the home visit performed by a nurse, and a second day of measurement in a representative sub-sample. Aim: To study the effect of these two additional actions over both the average value of BP and the national prevalence of hypertension. Material and Methods: A third blood pressure measurement was carried out in 5,058 subjects, and it was measured in a second day in 930 individuals. The effect of these additional measurements on absolute blood pressure values and the prevalence of hypertension were assessed. Results: A small but statistically significant reduction in mean systolic pressure (0.52 mmHg) and the prevalence of hypertension (1%) was observed after the incorporation of the third blood pressure measurement. No effects in these figures were observed after the measurement performed on a second day. Conclusions: These findings should be considered when designing the new National Health Survey in Chile.

Background: Signet ring cell (SRC) carcinoma of the stomach corresponds to 3 to 39% of all cases of gastric cancer. It tends to be less differentiated, infiltrative and diffuse. It is not clear if it has a different prognosis than other types of gastric cancer. Aim: to compare the survival of SRC gastric carcinoma with other types of gastric cancer, considering depth of gastric wall involvement and number of infiltrated lymphnodes. Material and Methods: Retrospective review of pathology samples of all gastric cancers operated between 1988 and 2005. Survival of patients with and without SRC gastric cancer was compared. Results: A total of 287 cases were reviewed. Of these 60 had a SRC gastric cancer. No differences in gastric wall infiltration between SRC and non SRC gastric cancer was observed. SRC gastric cancer has a higher frequency of lymph node involvement. No differences in survival between SRC and non SRC gastric cancer, were observed. Conclusions: In this retrospective series of patients, no differences in survival were observed between SRC and non SRC gastric cancer.

Objetivo: Comparar la sobrevida del cancer gástrico en anillo de sello (AS) con los otros tipos de adenocarcinoma (no anillo de sello (ÑAS)), según el compromiso en profundidad de la pared gástrica (T) y los números de linfonodos comprometidos (N). Material y Métodos: Se realizó un estudio de cohorte retrospectivo, en el cuál se seleccionó a todos los pacientes gastrectomizados por adenocarcinoma gástrico en el Hospital Base Valdivia entre los años 1988-2005. Se compararon los pacientes cuyo informe histopatológico concluía que el cancer gástrico era un AS (más del 50% de sus células son anillo de sello) con los que no lo eran (ÑAS). En el análisis estadístico se utiliza el test de %², Método de Kaplan Meier, test de Log Rank. Resultados: Total 287 casos. 60 AS y 227 ÑAS. No hubo diferencias estadísticamente significativas en cuanto a la profundidad tumoral entre ambos grupos. Los AS presentaron mayor compromiso linfonodal. Al comparar la sobrevida a 5 años de los AS con los ÑAS por estadio (TNM), no encontramos diferencias significativas. Conclusión: A la luz de este trabajo el tipo histológico anillo de sello no parece constituir un factor de mal pronóstico en el cancer gástrico.

Background: Rheumatic heart disease (RHD) is a delayed consequence of a pharyngeal infection with Group A streptococcus (GAS), usually ascribed to a cross-reactive immune response to the host cardiac tissues. Acute rheumatic fever (ARF) and its ensuing valvular sequelae are thus considered the prototype of a post-infectious autoimmune disease, with no direct evidence of residual streptococcal antigen in diseased valvular tissues. However, recent studies concerning the antigenic specificity and clonality of intralesional lymphocytes have revealed oligoclonal expansions characteristic of an antigen specific response, that might be related to GAS. Aim: To search for bacterial DNA in valvular tissue from RHD patients and controls. Material and methods: We extracted DNA from surgically excised valve specimens from 15 RHD patients and 6 non RHD controls and tested for the presence of bacterial DNA by Polymerase Chain Reaction (PCR) with primers for 16S rRNA. Results: Eighty percent (12/15) of valve specimens from RHD patients were positive for bacterial DNA, as opposed to none of the valves (n =6) from non RHD controls. Conclusions: These results suggest that GAS might persist in valvular tissue in patients with ARF and contribute to the inflammatory scarring lesion that leads to cardiovascular sequelae (Rev Méd Chile 2007; 135: 959-66)